Vol. 1 No. 1 (2014): Vol 1, Iss 1, Year 2014
Articles

EVALUATION OF WOUND HEALING ACTIVITY OF METHANOLIC EXTRACT OF SMILAX WIGHTII (A. DC.) IN WISTAR ALBINO RATS

Uma Maheswari P
Department of Botany, Kongunadu Arts and Science College, Tamilnadu, 641029, India.
Shalimol A
Department of Botany, Kongunadu Arts and Science College, Tamilnadu, 641029, India.
Arumugasamy A
Department of Botany, Kongunadu Arts and Science College, Tamilnadu, 641029, India.
Udhaya Sankar M.R
Department of Botany, Kongunadu Arts and Science College, Tamilnadu, 641029, India.
Published June 30, 2014
Keywords
  • Smilax wightii extract,
  • wound healing,
  • incision and excision wound models
How to Cite
P, U. M., A, S., A, A., & M.R, U. S. (2014). EVALUATION OF WOUND HEALING ACTIVITY OF METHANOLIC EXTRACT OF SMILAX WIGHTII (A. DC.) IN WISTAR ALBINO RATS. Kongunadu Research Journal, 1(1), 73-77. https://doi.org/10.26524/krj17

Abstract

The present experimental study was designed to evaluate the wound healing activity of methanolic extract of Smilax wightii A. DC. on incision and excision wound models in Wistar albino rats. The parameters studied were wound breaking strength, wound contraction area, epithelialization period, granulation tissue
wet, dry weight and hydroxyproline content in incision wound model, percentage of wound contraction and period of epithelialization in excision wound model. The rats were administered topically with 100mg/kg b.wt. (low dosage), 200mg/kg b.wt. (moderate dosage) and 500mg/kg b.wt. (high dosage) of methanolic
extract of Smilax wightii (MESW). The activity of the extract treated groups were compared with that of the control 1% Spirit. Framycetin sulphate 0.2% w/w was used as the standard drug. In incision wound model, there was a significant increase in the wound breaking strength in all the experimental groups treated with
MESW than that of the control. Similarly, significant (P<0.001) decrease in wound contraction area and period of epithelialization were also observed in the test group animals treated with MESW and the standard drug treated groups when compared to that of the control. , a significant increase was observed in granulation tissue wet and dry weight and hydroxyproline content in the test groups treated with MESW compared to the control. In exicision wound model, there was a significant increase (P<0.01) in the percentage of wound contraction and decrease in period of epithelialization in the experimental groups treated with 200mg/kgb.wt. (moderate dosage) and 500mg/kgb.wt (high dosage) of MESW. The extract treated groups showed significant improvement in all the wound healing parameters of incision, and excision wound models.

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