Kongunadu Research Journal
Vol. 1 No. 2 (2014): Vol 1, Iss 2, Year 2014
Articles

ANTI-HYPER LIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF SMILAX WIGHTII A.DC. IN STREPTOZOTOCIN INDUCED MALE WISTAR ALBINO RATS

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  • Uma Maheswari P,
  • Arumugasamy K,
  • Shalimol A,
  • Asha devi V,
  • Nantha kumar R
Uma Maheswari P
Department of Botany, Kongunadu Arts and Science College, Coimbatore
Arumugasamy K
Department of Botany, Kongunadu Arts and Science College, Coimbatore.
Shalimol A
Department of Botany, Kongunadu Arts and Science College, Coimbatore.
Asha devi V
Department of Botany, Kongunadu Arts and Science College, Coimbatore.
Nantha kumar R
Department of Botany, Kongunadu Arts and Science College, Coimbatore.
DOI: https://doi.org/10.26524/krj53
Published December 30, 2014
Keywords
  • Smilax wightii, anti-hyperlipidemic, streptozotocin, glibenclamide
How to Cite
P, U. M., K, A., A, S., V, A. devi, & R, N. kumar. (2014). ANTI-HYPER LIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF SMILAX WIGHTII A.DC. IN STREPTOZOTOCIN INDUCED MALE WISTAR ALBINO RATS. Kongunadu Research Journal, 1(2), 126-130. https://doi.org/10.26524/krj53

Abstract

Smilax wightii, an endemic medicinal plant is found in the shola forests at high altitudes in Nilgiri Biosphere Reserve, the Western Ghats, Southern India . The present study, was undertaken to find out the effect of methanolic extract of this plant on the body weight, fasting blood glucose levels and lipid profiles in
all the streptozotocin (STZ) induced rats. The extract exerted a significant (P<0.05) effect in the body weight of the experimental animals when compared to the control group. Treatment with the extract and glibenclamide resulted in a significant (P<0.01) reduction in the fasting blood glucose levels in diabetic rats
when compared to the normal. The lipid profile such as TC, TG, LDL, and VLDL contents in the serum registered a significant (P<0.01) hike and a decline in the HDL contents in diabetic control group, which were retrieved to near normalcy in the plant extract treated groups. The effect produced by this plant extract was
comparable with that of glibenclamide. The decreased fasting blood glucose levels and lipid lowering properties clearly showed the anti-hyperlipidemic effect of S.wightii.

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