An in vitro anticancerous and antioxidant potentials of the brown seaweed Sargassum polycystum C. Agardh

Abstract

Discovering new therapeutic agents for cancer treatment remains a significant issue in the search for a cure as, cancer is the preeminent reason of death worldwide. The majority of compounds used as chemotherapeutic medications to treat cancer have been found and isolated in plants for their synthetic derivatives. Biomaterials made from marine algae are crucial components of several medications used for the treatment of cancer and other diseases, due to their diverse bioactivities. The goal of the current study was to assess the marine algae Sargassum polycystum antioxidant capacity and anticancer efficacy against the A549 cell line. The antioxidants are crucial for preventing oxidative stress-related damage (OS). OS has been linked to the pathogenesis of several illnesses, including cancer, diabetes, and heart disease. Marine algae-derived natural compounds shield cells by reducing the effects of oxidative stress. From the algal extract DPPH radical scavenging activity in a concentration–dependent manner with maximum scavenging activity (IC50 value = 27.7±1.3µg/ml) was carried out. The in vitro anticancerous activity against the A549 Lung cancer cell line revealed that the IC50 value of Sargassum polycystum was 13±1.5 µg/ml. Thus we can deduce that the secondary metabolites from marine algae can advance with a substantial range of anti-cancerous medicaments.