HEPATOPROTECTIVE ACTIVITY OF ERIA MYSORENSIS LINDL. (ORCHIDACEAE) PSEUDOBULP AGAINST CARBONTETRACHLORIDE INDUCED TOXICITY

Abstract

The ethanolic extract of pseudobulb of Eria mysorensis at the dose of 100mg/kg body weight (oral) was studied for the hepatoprotective effect using Carbontetrachloride induced liver damage in wistar albino rats. Ethanolic extract showed significant (p<0.05) hepatoprotective effect by lowering the serum levels of various biochemical parameters such as serum Glutamic Oxaloacetate Transaminase (SGOT), Serum Glutamic Pyruvates Transaminase (SGPT), Alkaline Phospatase (ALP), Total Bilirubin (TBL), Total Cholesterol (CHL) and by increasing the levels of Total Protein (TPTN) and Albumin (ALB) in the selected model. These biochemical observations were inturn confirmed by histopathological examinations of liver sections and are comparable with the standard hepatoprotective drug Silymarin (100mg/kg body weight) which served as a positive control. The overall experimental results suggests that the biologically active phytoconstituents such as flavonoids, terpenoids, sterols, phenols, saponins and alkaloids present in the ethanolic extract of plant Eria mysorensis, may be responsible for the significant hepatoprotective activity and the results justify the use of Eria mysorensis as a hepatoprotective agent.